When done right, hyaluronic based dermal fillers look and feel great. But what if you have an unwanted side effect and the fillers don’t look the way they should? Hyaluronidase will save the day (and you)!

  • Remove unwanted or displaced fillers
  • Works 100% of the time over 24 hours
  • Restore your original look
  • No downtime & minimally invasive


Fast Facts:

About: Hyaluronidase is a substance administered intradermally to dissolve hyaluronic acid based dermal fillers and the results associated with them. Used on patients who have unsatisfactory, asymmetrical, or overfilled dermal filler results, Hyaluronidase is commonly used to reverse “botched” hyaluronic acid fillers.

Safety: FDA approved to reverse the effects of hyaluronic acid fillers, hyaluronidase is safe to use when administered by trained and experienced medical professionals and is associated with minimal side effects and zero downtime.

Convenience: Hyaluronidase injections are quick and relatively painless, allowing patients to dissolve their fillers within 10 minutes with zero downtime and minimal side effects.

Cost: Hyaluronidase injections prices may range $500 – $1500 per 1 session.

Efficacy: When used to reverse the effects of a hyaluronic acid based dermal filler, hyaluronidase has been clinically proven to be effective in fully dissolving hyaluronic acid fillers.

What is Hyaluronidase? How is Hyaluronidase used?

Hyaluronidase is an enzyme naturally produced by the body to break down hyaluronic acid, a naturally occurring molecule in the body responsible for skin and joint support and hydration. When a hyaluronic acid based dermal filler is injected into a given treatment area, hyaluronidase can be injected to undo its effects. 

While dermal fillers can have beautiful outcomes, poorly placed fillers or overfilled areas can look unattractive and a major cause for insecurity. In these cases, hyaluronidase can help remove excess volume or even out asymmetrically placed hyaluronic acid filler or lumpy, unattractive results.

Just as the popularity of dermal fillers has consistently grown over the past decade, the number of poorly placed fillers and inexperienced injectors has increased as well. While minimally invasive treatments are an incredible step up from the invasiveness of cosmetic surgery, poorly placed filler can lead to overfilling, puffiness, or lumpy filler outcomes with uneven facial contours and various side effects aside from the average swelling and bruising. Unfortunately this is not uncommon, which is why many dissatisfied patients from other clinics often come to Dr. Schwarzburg to get their dermal fillers dissolved using hyaluronidase injections. While hyaluronic acid fillers like Juvederm and Restylane naturally dissolve over time and there is always the option to wait for the filler to dissolve on its own, it can feel like an eternity when you feel that your face looks botched. Fortunately, there is a quicker and more efficient option available: hyaluronidase injections. 

Hyaluronidase offers a quick, effective, and immediate reversal of hyaluronic acid based dermal fillers, allowing patients to instantly resolve any filler mishap to get right back to their original state, or to get their fillers redone properly by a skilled and experienced injector. Dissolving filler before and after results are never a disappointment at Skinly.

How do hyaluronic acid-based fillers work?

Hyaluronic acid (HA) is a substance that is found naturally in the body, stimulating collagen production and providing hydration to the skin. As a glycosaminoglycan it binds collagen fibers, connective tissue, and proteins in the body. Hyaluronic acid based filler gels such as Juvederm and Restylane are used to add instant volume to the skin through intradermal injection. Most HA fillers utilize cross linking technology allowing the tiny gel molecules within the formulation to expand and most importantly last for several months. Hyaluronic acid based fillers can be used in various regions of the face and body for volume replacement, enhancement, wrinkle reduction and elimination, and contouring purposes, without the need for extensive downtime or side effects. However, not all dermal fillers are injected by skilled and experienced board certified cosmetic physicians, which is why the number of Hyaluronidase requests have risen. 

How does Hyaluronidase work?

What does hyaluronidase do? Hyaluronidase is a naturally occurring enzyme in the body produced by white blood cells to move through connective tissues in the body. In its injectable form, it is typically extracted from purified bovine tissue or human albumin sources.

Also called Hyaluronan, the hyaluronidase enzyme causes hydrolysis (the breakdown) of hyaluronic acid and is most commonly sold under the brand names Hydase, Hylenex, and Vitrase. When injected, this enzyme breaks down the hyaluronic acid links within HA fillers, accelerating the disintegration of the filler, allowing patients to instantly reverse the results of their dermal filler injections without affecting their own naturally occurring hyaluronic acid. This will also decrease the viscosity of the hyaluronic acid and increase tissue permeability.

In short, hyaluronidase is an injectable enzyme solution that instantly reverses the effects of hyaluronic acid based dermal fillers.

Where is Hyaluronidase used?

Hyaluronidase can be used in virtually any area in which a hyaluronic acid filler has been injected, from lip fillers and other facial filler enhancements to various regions of the body that may have been injected with HA. 

Medically it can be used for hypodermoclysis, which is fluid infusion through subcutaneous tissues used in pediatric care, to accelerate the diffusion of drugs and anesthetics for dispersion as well as delivery. It may also be used as a treatment for vitreous hemorrhage and in chemotherapy patients for the treatment of extravasation, also known as fluid leakage to circumvent skin cell injury. 

  • Dissolving filler in the face: People often get filler in their face in areas such as the forehead or chin. If you don’t like the way it looks, dermal filler removal is always possible with hyaluronidase.
  • Hyaluronidase under eyes: It is common to use an under eye filler to eliminate the hollows under your eyes, but if you are not pleased with the results, dissolving under-eye filler is simple.
  • Nose filler dissolved: Liquid nose jobs are a popular alternative to rhinoplasty, but sometimes, a smaller nose simply doesn’t suit your facial structure. You can rely on us at Skinly Aesthetics for dissolving Juvederm with hyaluronidase.
  • Dissolving filler in cheeks: Our cheeks tend to lose volume with age, which is why many people opt for filler. But if the results aren’t quite what you expected, dissolving cheek filler injections is the way to go. Dissolving cheek filler before and afters are common as they are often overfilled by inexperienced injectors.
  • Dissolving lip filler: Can you reverse lip injections? Yes. Getting a lip filler dissolved is one of the most popular uses for hyaluronidase. Some people don’t like the way filler makes their lips look, whereas others simply went too overboard. Our professionals can help you with having lip filler dissolved. The lip filler dissolver price depends on how much filler you have. 

Who is a candidate for Hyaluronidase injections?

If you are dissatisfied with a dermal filler and wondering how to dissolve Juvederm, then you are a candidate for hyaluronidase as long as the filler is a hyaluronic acid-based. While injectable dermal fillers typically are metabolized by the body within several months, there are some cases in which Dr. Schwarzburg receives new patients looking to dissolve a filler that has been sitting in the injected area for years. Regardless of when you received your dermal filler injections, Juvederm dissolver will permanently and immediately reverse its effects. You should always confirm with your provider that your filler is hyaluronic acid-based, as hyaluronidase is only able to dissolve HA.

If you have experienced anaphylaxis, are on certain medications, or have an allergy to any component of hyaluronidase, be sure to inform your provider to avoid any complications.

How do I prepare for my filler dissolving?

There is no preparation needed to get your filler dissolved. However, as hylenex to dissolve filler is injected, you should steer clear from blood thinners and alcohol for 2 – 5 days prior to your appointment to avoid potential bruising.

What is a hyaluronidase treatment like?

Before your procedure you will first consult with Dr. Schwarzburg so he can examine the area you want treated to see how much filler is there and how much product is needed to achieve your desired result.

After your evaluation, the treatment area will be sterilized and a topical lidocaine rich numbing cream may be applied. Once the numbing cream has settled, which typically takes 15 – 20 minutes, the area is sanitized once more before the injection process. 

Using an ultra-fine needle, Dr. Schwarzburg will inject the product into the area in which the filler is to be dissolved. This process is usually well tolerated by patients with minimal discomfort.

How long is a hyaluronidase procedure?

Depending on how much filler needs to be dissolved, the injection process itself typically lasts 5 – 15 minutes. If necessary, you may return to the clinic 3 – 5 days after your initial treatment to dissolve any remaining filler.

Are there any risks or side effects with dissolving filler?

Dissolving dermal fillers comes with very limited risks and side effects. Because this procedure does involve injections, you may experience some initial swelling and bruising which will subside within 1 – 3 days post-treatment.

Some patients fear that using hyaluronidase to dissolve their dermal fillers will leave them with less volume than they started with as it may also dissolve naturally occurring hyaluronic acid in the treated area. While this is incredibly rare, it would be a minor side effect as the body continuously produces HA.

It is crucial to find a skilled and reputable provider as removing a filler is just as much of an art as it is to inject it. For this reason it is recommended to find a board certified cosmetic physician or dermatologist to properly execute this procedure.

Is there aftercare for Hyaluronidase? Is there downtime?

Hyaluronidase requires no after care and has zero downtime. You may experience initial swelling and some bruising, in which case you can apply an ice pack to reduce the swelling, followed by a hot compress on day 2 to help reduce the bruising.

How much does Hyaluronidase cost?

You may be wondering, how much does it cost to dissolve lip filler? The cost of hyaluronidase is dependent on the amount of filler that needs to be dissolved, the qualifications and experience of your injector, as well as the geographical location of your provider. On average, you can expect to pay $500 – $2000 to dissolve your filler.

How is Hyaluronidase made? How to mix Hyaluronidase?

Hyaluronidase is obtained through naturally produced hyaluronidase through bovine or human albumin sources. While hyaluronidase for fillers is not typically diluted with saline or water, it is a highly complex substance in its injectable form and should only be administered by a board certified cosmetic physician using only FDA approved brands, such as Hylenex, Hydase, and Vitrase. Dr. Schwarzburg typically uses Hylenex on his patients as he has found it to be the most reliable and consistent amongst his large variety of patients.

Are there any Alternatives to remove hyaluronic acid fillers?

While hyaluronidase is the primary and most effective method to remove HA fillers, they can be aspirated briefly upon injection using a larger bore needle. You may be wondering how to dissolve filler naturally. Hyaluronic acid fillers do naturally dissolve over time, meaning that there is always the option of waiting it out and allowing your body to metabolize the filler on its own. This may take anywhere from 6 months to 2 years, and in some very rare cases several years.

Does Hyaluronidase dissolve your own tissue or natural hyaluronic acid?

While there is the common misconception that hyaluronidase will dissolve your naturally occurring hyaluronic acid, it does not actually dissolve your own hyaluronic acid or tissue. Hyaluronidase targets the hyaluronic acid linkage within HA dermal filler formulations, not the hyaluronic acid naturally and consistently produced by your body. There is no free floating hyaluronic acid in the tissues as all of it is contained within individual cells and hence it is not a target for hyaluronidase. 

Can Hyaluronidase be used if I have an allergic reaction to my hyaluronic acid filler?

Yes, hyaluronidase can dissolve your HA filler if you have an allergic reaction. However, depending on the severity of your allergic reaction, you may need additional treatments or medications to resolve the issue.

Can Hyaluronidase dissolve fat?

No, hyaluronidase does not dissolve fat and is specifically designed to dissolve hyaluronic acid fillers. While there are injectable treatments, such as Kybella, that can be used to break down fat in various regions of the face and body, hyaluronidase will not.

Do I need to have the filler removed?

Hyaluronic acid based dermal fillers are not permanent and dissolve over time (6 – 18 months depending on the filler), meaning that you don’t need to get them removed. However, in some cases, you may want to get your filler dissolved, for example if you were treated by an inexperienced injector, your dermal filler injection did not go as planned, is overfilled, asymmetrical, or simply just not your style after all. In this case, it is up to you to decide whether you’d like to dissolve it or not. If you go to a reputable clinic and a board certified physician to begin with, it is very unlikely for you to run into any of the above mentioned issues that may make you want to dissolve your filler.

How many Hyaluronidase sessions do I need? How much hyaluronidase is needed to dissolve filler?

Depending on how much filler there is to be dissolved, you may only need one 1 mL syringe of hyaluronidase to dissolve your dermal filler. This can be done in just one 10 minute session to fully dissolve your injections. In other cases you may need several syringes and sessions of hyaluronidase if you have a great deal of HA filler that you would like to reverse.

Do Hyaluronidase injections hurt?

Hyaluronidase injections are typically well tolerated by patients and are relatively painless. Dr. Schwarzburg often applies a topical numbing agent before the injection process to ease any discomfort. You may feel a slight pinch, though this feeling will not persist beyond the injection itself.

When will you see results from Hyaluronidase?

Depending on your individual case and how much filler you have, dissolving your filler can happen fairly quickly. The injection process itself usually takes no longer than 15 minutes, though you may experience some swelling and bruising afterwards, as you would with any injection. You should be able to observe the full result within 2 – 5 days after your hyaluronidase injections. If there is remaining filler that needs to be dissolved, you will come in for a touch-up to complete the treatment.

What kind of results can I expect from Hyaluronidase before and after treatment?

Before your treatment you will have a poorly placed, overfilled, asymmetrical, or generally unwanted HA dermal filler in one or more given areas. After your hyaluronidase injections, this unwanted filler will be dissolved and you will be left with the treated area looking the same way it had looked before you received your dermal fillers. This may be evident within hours post-injection, or within a few days depending on the initial amount of filler to be dissolved.

How long does it last?

Your HA filler will be permanently eliminated after the effects of your hyaluronidase procedure have manifested.

What if I want to get filler again?

Regardless of how often you dissolve your filler and where, you are able to refill the treated area once your hyaluronidase has settled. Before getting the area refilled, however, you will need an evaluation to confirm that no additional sessions are needed and the swelling has fully resolved.

Where can I buy Hyaluronidase?

Hyaluronidase can only be obtained and administered by a licensed medical professional. Anyone else is unable to purchase hyaluronidase for cosmetic injection. If you are wondering how to dissolve lip filler at home or how to self inject hyaluronic acid, you can’t. You will have to wait for your filler to metabolize on its own.

Is it covered by insurance?

For cosmetic purposes, hyaluronidase is not covered by insurance.

Does hyaluronidase work?

Hyaluronidase is FDA approved for cosmetic use to dissolve unwanted hyaluronic acid based dermal filler via intradermal injection. It works to immediately reverse the effects of your filler and is sold under various brand names, Hylenex being one of the most popular ones.

How long does filler dissolver take to work? How soon after dissolving lip filler can you get more?

Yes! Some patients claim to notice results in as little as one hour, though it is more common to see these results within 24 hours. However, you should expect to see the area take on its final shape in 1-2 days. You can get hyaluronic acid subcutaneous injection in the lips once your lips are no longer swollen after Juvederm hyaluronidase injections. Some may wonder, do lip fillers dissolve completely? They, can, but it may require several sessions depending on how much filler you have.

Is Hyaluronidase safe?

Yes, it is a safe treatment that only targets hyaluronic acid filler. It does not affect your skin, destroy your body’s own hyaluronic acid or cause hyaluronidase permanent damage. Hyaluronidase side effects are rare and there is zero downtime associated with this procedure.

What are pros and cons


  • Instantly reverses the effects of HA filler
  • Minimally invasive
  • Limited side effects or downtime


  • Can only dissolve hyaluronic acid based dermal fillers
  • May require more than one session


Hyaluronidase is a naturally occurring enzyme that can be injected into an area in which a hyaluronic acid filler was placed in order to dissolve it. The process takes approximately 15 minutes with instant results. There may be initial swelling and bruising, both of which subside within 24 hours to 3 days. Always be sure to consult with a board certified cosmetic physician, who can inject hyaluronic acid and knows how to dissolve under eye filler before undergoing a hylenex treatment in order to avoid adverse side effects.

How can I get started with my Hyaluronidase treatment?

If you have a HA dermal filler in your face or on your body that you would like to dissolve and are looking for hyaluronidase near me, then Skinly Aesthetics is your place to go. Owned and operated by Dr. Schwarzburg, you will be in the hands of an experienced board certified cosmetic physician with over a decade of experience in the field. Dr. Schwarzburg prioritizes the safety of his patients and will effectively eliminate your unwanted dermal filler and skillfully refill the affected area to meet your needs.

You can schedule your consultation with Dr. Schwarzburg by calling or texting Skinly Aesthetics at (212) 774-4264 or emailing us at info@skinlyaesthetics.com.